abstract：BACKGROUND:As a member of peroxiredoxin (PRX) family, PRX3 is predominantly located in mitochondria and plays an important role of free radical scavenging. Since a body of evidence demonstrated the involvement of PRX3 in insulin secretion, insulin sensitivity, and glucose metabolism, the present study was conducted to ...

journal_title：BMC endocrine disorders

authors： Liu HL,Li TT,Yu AQ,Li J,Li X,Li L,Kaifu T

更新日期：2019-03-14 00:00:00

abstract：BACKGROUND:As an insulin-dependent disease, type 1 diabetes requires paying close attention to the glycemic control. Studies have shown that mobile health (mHealth) can improve the management of chronic diseases. However, the effectiveness of mHealth in controlling the glycemic control remains uncertain. The objective ...

journal_title：BMC endocrine disorders

authors： Wang X,Shu W,Du J,Du M,Wang P,Xue M,Zheng H,Jiang Y,Yin S,Liang D,Wang R,Hou L

更新日期：2019-02-13 00:00:00

abstract：BACKGROUND:Sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3) proteins have an important role in counteracting oxidative stress. Although diabetes and hypothyroidism (HT) are both characterized by oxidative stress, the mechanisms are not fully understood. This study investigated the effects of type 1 diabetes (T1D), type 2 diabet...

journal_title：BMC endocrine disorders

authors： Al-Khaldi A,Sultan S

更新日期：2019-02-08 00:00:00

abstract：BACKGROUND:Insulin and insulin-like growth factor (IGF)-1 coupled with growth hormone helps control timing of sexual maturation. Mutations and variants in multiple genes are associated with development or reduced risk of central precocious puberty (CPP). METHODS:We assessed single nucleotide polymorphisms (SNPs) in th...

journal_title：BMC endocrine disorders

authors： Chang HP,Yang SF,Wang SL,Su PH

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:The aim of the present study is to evaluate the association between BMD and type 2 DM status in middle-aged and elderly men. To investigate a possible correlation, the present study used the BMD dataset of the Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011. METHODS:In tot...

journal_title：BMC endocrine disorders

authors： Jang M,Kim H,Lea S,Oh S,Kim JS,Oh B

更新日期：2018-09-05 00:00:00

abstract：BACKGROUND:Vitamin D deficiency is pandemic while resources available to measure 25-hydroxyvitamin D (25OHD) are limited. The present study aimed to verify whether sun exposure measured by a structured questionnaire could predict serum 25OHD concentrations in healthy Caucasian individuals living in a tropical area. ME...

journal_title：BMC endocrine disorders

authors： Bittar FB,Castro CHM,Szejnfeld VL

更新日期：2018-07-03 00:00:00

abstract：BACKGROUND:Diabetes mellitus is usually preceded by a pre-diabetic stage before the clinical presentation of the disease, the influence of which on persons' quality of life is not adequately elucidated. The purpose of this study was to compare the Health-Related Quality of Life (HRQOL) of persons with pre-diabetes with...

journal_title：BMC endocrine disorders

authors： Makrilakis K,Liatis S,Tsiakou A,Stathi C,Papachristoforou E,Perrea D,Katsilambros N,Kontodimopoulos N,Niakas D

更新日期：2018-05-29 00:00:00

abstract：BACKGROUND:Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is caused by tumours releasing ACTH. Ectopic ACTH-producing tumour regression is rarely induced using steroidogenesis inhibitors. We presented a case of EAS in which ACTH production by a lung tumour was reduced by metyrapone (MTP) and also reviewed pr...

journal_title：BMC endocrine disorders

authors： Iwayama H,Hirase S,Nomura Y,Ito T,Morita H,Otake K,Okumura A,Takagi J

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Limited real-world data are currently available on hypoglycemia in diabetes patients. The International Operations Hypoglycemia Assessment Tool (IO HAT) study was designed to estimate hypoglycemia in insulin-treated type I (T1DM) and type II (T2DM) diabetes mellitus patients from 9 countries. The data from T...

journal_title：BMC endocrine disorders

authors： Emral R,Tetiker T,Sahin I,Sari R,Kaya A,Yetkin İ,Cil SU,Tütüncü NB,IO HAT investigator group.

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND:The association between thyroid nodules and adiposity remains controversial. We performed a cross-sectional, community-based study to examine whether thyroid nodules are associated with overweight and obesity, as defined with body mass index (BMI) and waist circumference. METHODS:The study included 1482 sub...

journal_title：BMC endocrine disorders

authors： Song B,Zuo Z,Tan J,Guo J,Teng W,Lu Y,Liu C

更新日期：2018-01-27 00:00:00

abstract：BACKGROUND:The hypertension cure rate of unilateral adrenalectomy in primary aldosteronism (PA) patients varies widely in existing studies. METHODS:We conducted an observational meta-analysis to summarize the pooled hypertension cure rate of unilateral adrenalectomy in PA patients. Comprehensive electronic searches of...

journal_title：BMC endocrine disorders

authors： Zhou Y,Zhang M,Ke S,Liu L

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:There are multiple criteria to define remission of type 2 diabetes (DM2) after bariatric surgery but there is not a specific one widely accepted. Our objectives were to compare diagnostic criteria for DM2 remission after bariatric surgery: Criteria from Spanish scientific associations (SEEN/SEEDO/SED) and fr...

journal_title：BMC endocrine disorders

authors： Alhambra-Expósito MR,Molina-Puerta MJ,Prior-Sánchez MI,Manzano-García G,Calañas-Continente A,Gálvez-Moreno MA

更新日期：2017-08-15 00:00:00

abstract：BACKGROUND:Spontaneous haemorrhage into a parathyroid adenoma is a rare and potentially life-threatening presentation. CASE PRESENTATION:We report the case of a 45 year old female recently diagnosed with primary hyperparathyroidism who presented with chest discomfort and acute airway compromise due to spontaneous extr...

journal_title：BMC endocrine disorders

authors： Garrahy A,Hogan D,O'Neill JP,Agha A

更新日期：2017-06-21 00:00:00

abstract：BACKGROUND:Subclinical hypothyroidism (SH) is associated with adverse obstetric outcomes and neurodevelopment disorders. Both iodine deficiency and excess are associated with SH; however, few data regarding iodine nutrition status of pregnant women with SH are available. This study aimed to clarify whether iodine defic...

journal_title：BMC endocrine disorders

authors： Wang K,Zhang J,Li F,Zhang W,Wang H,Ding L,Liu Y,Lin L,Zhang S,Zhu M

更新日期：2017-02-17 00:00:00

abstract：BACKGROUND:We determined the proportion of the effects of body mass index (BMI) or its categories on cardiometabolic outcomes mediated through systolic blood pressure (SBP), total cholesterol and fasting glucose. METHODS:Cox regression analyses were performed for incident outcomes among Turkish Adult Risk Factor study...

journal_title：BMC endocrine disorders

authors： Can G,Onat A,Yurtseven E,Karadeniz Y,Akbaş-Şimşek T,Kaya A,Yüksel H

更新日期：2016-09-29 00:00:00

abstract：BACKGROUND:Early identification of children and adolescents with type 1 diabetes at high risk for development of complications is important, as early intervention may prevent further deterioration. Here we investigate the applicability of assessing skin advanced glycation end products (sAGEs) by skin autofluorescence (...

journal_title：BMC endocrine disorders

authors： van der Heyden JC,Birnie E,Mul D,Bovenberg S,Veeze HJ,Aanstoot HJ

更新日期：2016-09-09 00:00:00

abstract：BACKGROUND:Diabetic foot ulceration is receiving more attention because of its high amputation and mortality rate. It is essential to establish the frequency of amputations in people with diabetes after any change to the management of diabetic foot care. The present study aim to compare the frequency of lower-extremity...

journal_title：BMC endocrine disorders

authors： Wang C,Mai L,Yang C,Liu D,Sun K,Song W,Luo B,Li Y,Xu M,Zhang S,Li F,Ren M,Yan L

更新日期：2016-07-07 00:00:00

abstract：:Hypopituitarism is deficiency of one or more pituitary hormones, of which adrenocorticotrophic hormone (ACTH) deficiency is the most serious and potentially life-threatening. It may occur in isolation or, more commonly as part of more widespread pituitary failure. Diagnosis requires demonstration of subnormal cortisol...

journal_title：BMC endocrine disorders

authors： Garrahy A,Agha A

更新日期：2016-06-17 00:00:00

abstract：:Oxytocin (OT) emerges as a drug for the treatment of diabetes and obesity. The entire OT system is synthesized in the rat and human heart. The direct myocardial infusion with OT into an ischemic or failing heart has the potential to elicit a variety of cardioprotective effects. OT treatment attenuates cardiomyocyte (C...

journal_title：BMC endocrine disorders

authors： Jankowski M,Broderick TL,Gutkowska J

更新日期：2016-06-07 00:00:00

abstract：BACKGROUND:In order to accurately interpret neonatal thyroid function tests (TFTs), it is necessary to have population specific reference intervals (RIs) as there is significant variation across different populations possibly due to genetic, environmental or analytical issues. Despite the importance of RIs, globally th...

journal_title：BMC endocrine disorders

authors： Omuse G,Kassim A,Kiigu F,Hussain SR,Limbe M

更新日期：2016-05-23 00:00:00

abstract：BACKGROUND:Islet cell transplantation is a method to stabilize type 1 diabetes patients with hypoglycemia unawareness and unstable blood glucose levels by reducing insulin dependency and protecting against severe hypoglycemia through restoring endogenous insulin secretion. This study analyses the current cost-effective...

journal_title：BMC endocrine disorders

authors： Wallner K,Shapiro AM,Senior PA,McCabe C

更新日期：2016-04-09 00:00:00

abstract：BACKGROUND:The aim of the present study of the general population was to identify the best predictor of metabolic risk among the body index variables evaluated with dual-energy X-ray absorptiometry (DEXA) or anthropometric indices including the waist to height ratio (WHtR). PATIENTS AND METHODS:Data from the Korean Na...

journal_title：BMC endocrine disorders

authors： Kang SH,Cho KH,Park JW,Do JY

更新日期：2015-12-08 00:00:00

abstract：BACKGROUND:Type 2 diabetic patients display significantly higher incidence of cardiovascular (CV) events including stroke compared to non-diabetics. Morning blood pressure surge (MBPS) and blunted systolic night-day (SND) ratio have been associated with CV events in hypertensive patients. No studies have evaluated MBPS...

journal_title：BMC endocrine disorders

authors： Lyhne JM,Laugesen E,Høyem P,Cichosz S,Christiansen JS,Knudsen ST,Hansen KW,Hansen TK,Poulsen PL

更新日期：2015-12-03 00:00:00

abstract：BACKGROUND:The nonthyroidal illness syndrome (NTIS) is prevalent among patients with enterocutaneous fistula and is associated with poor outcomes. The present study aimed to explore the role of enteral nutrition (EN) therapy on thyroid function among patients with enterocutaneous fistula and NTIS. METHODS:We conducted...

journal_title：BMC endocrine disorders

authors： Li R,Ren J,Wu Q,Wang G,Wu X,Chen J,Li G,Hong Z,Ren H,Zhao Y,Li J

更新日期：2015-11-04 00:00:00

abstract：BACKGROUND:Hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome is a rare autosomal dominant disorder caused by mutations in the zinc finger transcription factor gene, GATA3. GATA3 has 2 zinc finger domains, which play an important role in the increase in target gene transcription activity. CASE PRESENTATI...

journal_title：BMC endocrine disorders

authors： Okawa T,Yoshida M,Usui T,Kudou T,Iwasaki Y,Fukuoka K,Takahashi N,Uehara Y,Oiso Y

更新日期：2015-10-30 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is becoming a serious health problem; the number of people with impaired renal function is rapidly rising. Progression of CKD is associated with having a number of complications, including thyroid dysfunction, dyslipidemia and cardiovascular diseases. This study was conducted to ...

journal_title：BMC endocrine disorders

authors： Khatiwada S,Rajendra KC,Gautam S,Lamsal M,Baral N

更新日期：2015-10-29 00:00:00

abstract：BACKGROUND:Addison's disease, or primary adrenal insufficiency, is often associated with reduced well-being and fatigue despite use of currently recommended adrenal hormone replacement. Hypoglycaemia is a known manifestation of glucocorticoid deficiency, but is generally considered rare in adults and not relevant to tr...

journal_title：BMC endocrine disorders

authors： Petersen KS,Rushworth RL,Clifton PM,Torpy DJ

更新日期：2015-10-24 00:00:00

abstract：BACKGROUND:Diabetes mellitus (DM) leads to multiple complications, including severe hypoglycaemia events (SHEs). SHEs can impact a patient's quality of life and compliance and may directly result in additional costs to the health care system. The aim of this review was to evaluate the risk of severe hypoglycaemia in pa...

journal_title：BMC endocrine disorders

authors： Czech M,Rdzanek E,Pawęska J,Adamowicz-Sidor O,Niewada M,Jakubczyk M

更新日期：2015-10-12 00:00:00

abstract：BACKGROUND:Among patients with type 2 diabetes, insulin intensification to achieve glycemic targets occurs less often than clinically indicated. Barriers to intensification are not well understood. We present patients' baseline characteristics from MOSAIc, a study investigating patient-, physician-, and healthcare envi...

journal_title：BMC endocrine disorders

authors： Polinski JM,Kim SC,Jiang D,Hassoun A,Shrank WH,Cos X,Rodríguez-Vigil E,Suzuki S,Matsuba I,Seeger JD,Eddings W,Brill G,Curtis BH

更新日期：2015-09-09 00:00:00

abstract：BACKGROUND:There have only been a few reports about use of dipeptidyl peptidase 4 (DPP-4) inhibitors in elderly patients with type 2 diabetes mellitus (T2DM), suggesting that the safety of these agents has not been sufficiently demonstrated. We performed a comparative review of the efficacy and safety of sitagliptin fo...

journal_title：BMC endocrine disorders

authors： Umezawa S,Kubota A,Maeda H,Kanamori A,Matoba K,Jin Y,Minagawa F,Obana M,Iemitsu K,Ito S,Amamiya H,Kaneshiro M,Takai M,Kaneshige H,Hoshino K,Ishikawa M,Minami N,Takuma T,Sasai N,Aoyagi S,Kawata T,Mokubo A,Miyai

更新日期：2015-07-03 00:00:00

abstract：BACGROUND:To assess the contribution of macroprolactin to high serum prolactin levels and their association with thyroid status and thyroid autoimmunity during pregnancy. METHODS:138 pregnant women who suspected of having thyroid dysfunction were studied and divided into three groups according to the thyroid status; g...

journal_title：BMC endocrine disorders

authors： Guclu M,Cander S,Kiyici S,Vatansever E,Hacihasanoğlu AB,Kisakol G

更新日期：2015-06-20 00:00:00

abstract：BACKGROUND:While poor sleep quality can worsen cardiovascular risk factors such as glucose and lipid profiles in patients with type 2 diabetes mellitus (T2DM), the relationship between sleep quality and atherosclerosis remains largely unknown. The aim of this study was to examine this relationship. METHODS:The study p...

journal_title：BMC endocrine disorders

authors： Osonoi Y,Mita T,Osonoi T,Saito M,Tamasawa A,Nakayama S,Someya Y,Ishida H,Kanazawa A,Gosho M,Fujitani Y,Watada H

更新日期：2015-06-18 00:00:00

abstract：BACKGROUND:The hormone somatostatin inhibits growth hormone release from the pituitary gland and is theoretically linked to diabetes and diabetes related complications. This study aimed to investigate the relationship between levels of the stable somatostatin precursor, N-terminal prosomatostatin (NT-proSST), with mort...

journal_title：BMC endocrine disorders

authors： van Dijk PR,Landman GW,van Essen L,Struck J,Groenier KH,Bilo HJ,Bakker SJ,Kleefstra N

更新日期：2015-04-14 00:00:00

abstract：BACKGROUND:Primary care physicians (PCPs) are the main providers of diabetes care especially in resource-limited countries which experience extreme shortage of specialists. The present study aimed to evaluate PCPs' approach towards diabetes mellitus (DM) diagnosis, evaluation and management in Cameroon. METHODS:We car...

journal_title：BMC endocrine disorders

authors： Jingi AM,Nansseu JR,Noubiap JJ

更新日期：2015-04-04 00:00:00

abstract：BACKGROUND:Children whose mothers had low thyroid hormone levels during pregnancy have been reported to have decreased cognitive function. The reported research is part of the follow-on study of the Controlled Antenatal Thyroid Screening Study (CATS I), a randomised controlled trial which investigated the impact of tre...

journal_title：BMC endocrine disorders

authors： Hales C,Channon S,Taylor PN,Draman MS,Muller I,Lazarus J,Paradice R,Rees A,Shillabeer D,Gregory JW,Dayan CM,Ludgate M

更新日期：2014-12-12 00:00:00

abstract：BACKGROUND:In primary health care systems where member's turnover is relatively low, the question, whether investment in quality of care improvement can make a business case, or is cost effective, has not been fully answered.The objectives of this study were: (1) to investigate the relationship between improvement in s...

journal_title：BMC endocrine disorders

authors： Wilf-Miron R,Bolotin A,Gordon N,Porath A,Peled R

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:We report the case of a patient who had a non-functional metastatic pancreatic neuroendocrine tumour (pNET), which changed in functionality during the course of the disease. This case demonstrates the effectiveness of conventional cytotoxic chemotherapy in the management of select group of patients with this...

journal_title：BMC endocrine disorders

authors： Rajeev SP,McDougall S,Terlizzo M,Palmer D,Daousi C,Cuthbertson DJ

更新日期：2014-08-24 00:00:00

abstract：BACKGROUND:Promyelocytic leukaemia zinc finger (PLZF) is a transcriptional repressor that was originally isolated from a patient with promyelocytic leukaemia. PLZF also affects key elements for cell cycle progression, such as cyclin A, and can affect the tumourigenicity of various cancers. Thus far, the behaviour of PL...

journal_title：BMC endocrine disorders

authors： Matsuzawa K,Izawa S,Ohkura T,Ohkura H,Ishiguro K,Yoshida A,Takiyama Y,Haneda M,Shigemasa C,Yamamoto K,Taniguchi S

更新日期：2014-07-03 00:00:00

abstract：BACKGROUND:Mexican Americans are at an increased risk of both thyroid dysfunction and metabolic syndrome (MS). Thus it is conceivable that some components of the MS may be associated with the risk of thyroid dysfunction in these individuals. Our objective was to investigate and replicate the potential association of MS...

journal_title：BMC endocrine disorders

authors： Mamtani M,Kulkarni H,Dyer TD,Almasy L,Mahaney MC,Duggirala R,Comuzzie AG,Samollow PB,Blangero J,Curran JE

更新日期：2014-06-10 00:00:00

abstract：BACKGROUND:11 patients were referred to our Molecular Genetics Department at the Royal Devon and Exeter Hospital between 2000-2012 with a physician's diagnosis of remitting diabetes. Our aim was to identify patients with remitting diabetes whose clinical presentation is not explained by any known aetiology of diabetes....

journal_title：BMC endocrine disorders

authors： Babiker T,Chakera AJ,Shepherd M,Hattersley AT

更新日期：2014-06-09 00:00:00